De novo design of functional proteins: Toward artificial hydrogenases

Marina Faiella, Anindya Roy, Dayn Sommer, Giovanna Ghirlanda

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


Over the last 25 years, de novo design has proven to be a valid approach to generate novel, well-folded proteins, and most recently, functional proteins. In response to societal needs, this approach is been used increasingly to design functional proteins developed with an eye toward sustainable fuel production. This review surveys recent examples of bioinspired de novo designed peptide based catalysts, focusing in particular on artificial hydrogenases.

Original languageEnglish (US)
Pages (from-to)558-571
Number of pages14
Issue number6
StatePublished - Nov 2013


  • Catalysis
  • De novo design
  • Hydrogenase
  • Iron-sulfur clusters
  • Peptide

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Biomaterials
  • Organic Chemistry


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