Computer Aided Tissue Engineering for Modeling and Design of Novel Tissue Scaffolds

Computer-aided tissue engineering (CATE) integrates advances of multi-disciplinary fields of Biology, Biomedical Engineering, Information Technology, and modern Design and Manufacturing. Application of CATE to the design and fabrication of tissue scaffolds can facilitate the exploration of many novel ideas of incorporating biomimetic and biological features into the scaffold design. This paper presents some of the salient applications of CATE, particularly in the modeling and design of scaffolds with controlled internal and external architecture; with vascular channels of different sizes; with modular and interconnecting subunits; with multi-layered heterogeneous dense and compact regions; and the scaffolds with designed artificial chambers for drug delivery, embedded growth factors and other sophisticated features.