Complex dynamics in coupled cardiac pacemaker cells

Dongming Cai, Ying Cheng Lai, Raimond L. Winslow

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


We investigate the dynamics of a model of electrically coupled pacemaking cardiac sino-artial node cells. Cell models are biophysically detailed, and include voltage-dependent membrane currents, pump-exchanger currents, and time-varying internal ion concentration changes similar to those seen in real sino-atrial node cells. It is found that at low, yet physiologically realistic coupling conductance values, complex dynamics including chaos can arise. Occurrence of these complex dynamics in coupled pacemaker cells may provide an explanation for the origin of certain cardiac arrhythmias.

Original languageEnglish (US)
Pages (from-to)2501-2504
Number of pages4
JournalPhysical Review Letters
Issue number15
StatePublished - 1993
Externally publishedYes

ASJC Scopus subject areas

  • General Physics and Astronomy


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