Complement component C1q unaltered by ascorbate supplementation in healthy men and women

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3 Scopus citations


In the guinea pig, ascorbate administration elevated plasma C1q values 30 to 50% over control values. To determine the effects of vitamin supplementation on C1q in man, healthy men and women (n = 14) consumed placebo capsules for 4 weeks and ascorbate supplements, 1500 mg/d, for 4 weeks, in a double-blind, cross-over fashion. Subjects ate self-selected diets but were instructed to avoid vitamin C-rich foods during the 8-week experimental period. Fasting blood samples, collected at the start of the study and at the end of weeks 4 and 8, were analyzed for ascorbate and C1q, measured directly by immunodiffusion against anti-human C1q. Compared to placebo values, plasma ascorbate rose 92% following the 4-week supplementation period, and plasma C1q rose 18%. The rise in C1q following ascorbate administration was not significant (P = 0.12). Furthermore, plasma ascorbate was not correlated with C1q (r = 0.21, P = 0.14). Hence, in healthy men and women, ascorbate supplementation, at levels 25 times that which is recommended, did not significantly alter plasma Clq levels.

Original languageEnglish (US)
Pages (from-to)499-501
Number of pages3
JournalThe Journal of Nutritional Biochemistry
Issue number9
StatePublished - Sep 1991


  • ascorbic acid
  • complement component Clq

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Molecular Biology
  • Nutrition and Dietetics
  • Clinical Biochemistry


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