Comparative analyses reveal a complex history of molecular evolution for human MYH16

George H. Perry, Brian C. Verrelli, Anne Stone

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


We describe the pattern of molecular evolution at a sarcomeric myosin gene, MYH16, using more than 30,000 bp of exon and intron sequence data from the chimpanzee and human genome sequencing projects to evaluate the timing and consequences of a human lineage-specific frameshift deletion. We estimate the age of the deletion at approximately 5.3 MYA. This estimate is consistent with the time of human and chimpanzee divergence and is significantly older than the first appearance of the genus Homo in the fossil record. We also find conflicting estimates of nonsynonymous fixation rates (dN) across different regions of this gene, revealing a complex pattern inconsistent with a simple model of pseudogene evolution for human MYH16.

Original languageEnglish (US)
Pages (from-to)379-382
Number of pages4
JournalMolecular biology and evolution
Issue number3
StatePublished - Mar 2005


  • MYH16
  • Macaca mulatta
  • Pan troglodytes
  • Sarcomeric myosin

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics


Dive into the research topics of 'Comparative analyses reveal a complex history of molecular evolution for human MYH16'. Together they form a unique fingerprint.

Cite this