Colorimetric Sensor for Online Accurate Detection of Breath Acetone

Di Wang, Fenni Zhang, Amlendu Prabhakar, Xingcai Qin, Erica S. Forzani, Nongjian Tao

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


Breath acetone (BrAce) is a validated biomarker of lipid oxidation and has been extensively studied for many applications, such as monitoring ketoacidosis in diabetes, guiding ketogenic diet, and measuring fat burning during exercise. Although many sensors have been reported for BrAce measurement, most of the contributions tested only synthetic or spiked breath samples, because of the complex components of human breath. Here, we show that online accurate detection of BrAce can be achieved using a colorimetric sensor. The high selectivity is enabled by the specific reaction between acetone and hydroxylamine sulfate, and the sensor has a high agreement with a reference instrument in ketosis monitoring. We anticipate that the colorimetric acetone sensor can be applied to various health-related applications.

Original languageEnglish (US)
Pages (from-to)450-453
Number of pages4
JournalACS sensors
Issue number2
StatePublished - Feb 26 2021


  • acetone sensor
  • breath analysis
  • colorimetry
  • hand-held device
  • ketosis monitoring

ASJC Scopus subject areas

  • Bioengineering
  • Instrumentation
  • Process Chemistry and Technology
  • Fluid Flow and Transfer Processes


Dive into the research topics of 'Colorimetric Sensor for Online Accurate Detection of Breath Acetone'. Together they form a unique fingerprint.

Cite this