Cliff-edged fitness functions and the persistence of schizophrenia

Randolph M. Nesse

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Strong recent selection for social cognition may well explain the persistence of genes that predispose to schizophrenia. The specific mechanism responsible may be a skewed fitness function in which selection pushes the mean for advantageous mental traits perilously close to a "fitness cliff" where the system fails catastrophically in some individuals.

Original languageEnglish (US)
Pages (from-to)862-863
Number of pages2
JournalBehavioral and Brain Sciences
Issue number6
StatePublished - Dec 2004
Externally publishedYes

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Physiology
  • Behavioral Neuroscience


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