Cholangiocarcinoma: Expanding the spectrum of risk factors

Diaa H. Elfaki, Andrea A. Gossard, Keith D. Lindor

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Introduction: Cholangiocarcinoma (CCA) is an epithelial cancer originating from the bile ducts with features of cholangiocyte differentiation. The global incidence of this rare disease is on the rise, and it is the second most common primary hepatobiliary malignancy. We reviewed risk factors for cholangiocarcinoma development and also described potential screening strategies for this malignancy. We also report two cases in which CCA developed in patients without previously determined risk factors known for CCA. Discussion: The first case is a patient with longstanding secondary sclerosing cholangitis (SSC), and the second is a patient with autoimmune hepatitis (AIH). These two cases may indicate a possible association between SSC and AIH with CCA, thus, expanding the spectrum of risk factors of CCA.

Original languageEnglish (US)
Pages (from-to)114-117
Number of pages4
JournalJournal of Gastrointestinal Cancer
Issue number1-4
StatePublished - Mar 1 2008
Externally publishedYes


  • Autoimmune hepatitis
  • Cholangiocarcinoma
  • Primary sclerosing cholangitis
  • Secondary sclerosing cholangitis

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology


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