Chemokine oligomerization in cell signaling and migration

Xu Wang, Joshua S. Sharp, Tracy M. Handel, James H. Prestegard

Research output: Chapter in Book/Report/Conference proceedingChapter

37 Scopus citations


Chemokines are small proteins best known for their role in controlling the migration of diverse cells, particularly leukocytes. Upon binding to their G-protein-coupled receptors on the leukocytes, chemokines stimulate the signaling events that cause cytoskeletal rearrangements involved in cell movement, and migration of the cells along chemokine gradients. Depending on the cell type, chemokines also induce many other types of cellular responses including those related to defense mechanisms, cell proliferation, survival, and development. Historically, most research efforts have focused on the interaction of chemokines with their receptors, where monomeric forms of the ligands are the functionally relevant state. More recently, however, the importance of chemokine interactions with cell surface glycosaminoglycans has come to light, and in most cases appears to involve oligomeric chemokine structures. This review summarizes existing knowledge relating to the structure and function of chemokine oligomers, and emerging methodology for determining structures of complex chemokine assemblies in the future.

Original languageEnglish (US)
Title of host publicationOligomerization in Health and Disease
PublisherElsevier B.V.
Number of pages48
ISBN (Print)9780123869319
StatePublished - 2013

Publication series

NameProgress in Molecular Biology and Translational Science
ISSN (Print)1877-1173


  • Cell migration
  • Chemokine
  • Chemokine receptor
  • Glycosaminoglycan
  • Mass spectrometry
  • Nuclear magnetic resonance
  • Oligomerization
  • Small angle X-ray scattering
  • Structure

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology


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