Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels

Indrajit Bandyopadhyay; Sandipan Roy Chowdhury; Nishant P. Visavadiya; Sidney Hecht; Omar Khdour

doi:10.1016/j.dib.2018.08.156

Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels

Indrajit Bandyopadhyay
, Sandipan Roy Chowdhury
, Nishant P. Visavadiya
, Sidney Hecht
, Omar Khdour

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

As part of an ongoing program to develop potential therapeutic agents for the treatment of the neurodegenerative disease Friedreich׳s ataxia (FRDA), we have prepared a number of lipophilic methylene blue analogues. Some of these compounds significantly increase mitochondrial biogenesis and frataxin levels in cultured Friedreich's ataxia cells [1]. This data article describes the chemical synthesis and full physicochemical characterization of the new analogues.

Original language	English (US)
Pages (from-to)	1105-1114
Number of pages	10
Journal	Data in Brief
Volume	20
DOIs	https://doi.org/10.1016/j.dib.2018.08.156
State	Published - Oct 2018

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title = "Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels",

abstract = "As part of an ongoing program to develop potential therapeutic agents for the treatment of the neurodegenerative disease Friedreich׳s ataxia (FRDA), we have prepared a number of lipophilic methylene blue analogues. Some of these compounds significantly increase mitochondrial biogenesis and frataxin levels in cultured Friedreich's ataxia cells [1]. This data article describes the chemical synthesis and full physicochemical characterization of the new analogues.",

author = "Indrajit Bandyopadhyay and Chowdhury, \{Sandipan Roy\} and Visavadiya, \{Nishant P.\} and Sidney Hecht and Omar Khdour",

note = "Publisher Copyright: {\textcopyright} 2018",

year = "2018",

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doi = "10.1016/j.dib.2018.08.156",

language = "English (US)",

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T1 - Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels

AU - Bandyopadhyay, Indrajit

AU - Chowdhury, Sandipan Roy

AU - Visavadiya, Nishant P.

AU - Hecht, Sidney

AU - Khdour, Omar

PY - 2018/10

Y1 - 2018/10

N2 - As part of an ongoing program to develop potential therapeutic agents for the treatment of the neurodegenerative disease Friedreich׳s ataxia (FRDA), we have prepared a number of lipophilic methylene blue analogues. Some of these compounds significantly increase mitochondrial biogenesis and frataxin levels in cultured Friedreich's ataxia cells [1]. This data article describes the chemical synthesis and full physicochemical characterization of the new analogues.

AB - As part of an ongoing program to develop potential therapeutic agents for the treatment of the neurodegenerative disease Friedreich׳s ataxia (FRDA), we have prepared a number of lipophilic methylene blue analogues. Some of these compounds significantly increase mitochondrial biogenesis and frataxin levels in cultured Friedreich's ataxia cells [1]. This data article describes the chemical synthesis and full physicochemical characterization of the new analogues.

UR - https://www.scopus.com/pages/publications/85053182577

UR - https://www.scopus.com/pages/publications/85053182577#tab=citedBy

U2 - 10.1016/j.dib.2018.08.156

DO - 10.1016/j.dib.2018.08.156

M3 - Article

AN - SCOPUS:85053182577

SN - 2352-3409

VL - 20

SP - 1105

EP - 1114

JO - Data in Brief

JF - Data in Brief

ER -

Chemical synthesis of lipophilic methylene blue analogues which increase mitochondrial biogenesis and frataxin levels

Abstract

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