Changes in neurocranium thickness in early childhood

Niharika Gajawelli, Sean Deoni, Jie Shi, Liang Xu, Holly Dirks, Douglas Dean, Jonathan O'Muircheartaigh, Siddhant Sawardekar, Andrea Ezis, Marvin D. Nelson, Yalin Wang, Natasha Lepore

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


Several developmental disorders involve shape abnormalities of the neurocranium, the most common one being craniosynostosis, that affects about 1 in 2000 infants. A key step in determining how these disorders affect neurodevelopment is to establish how the brain and neurocranium co-evolve in the normally developing child. However, due to the scarcity of normally developing infant and pediatric imaging data, there have been a lack of imaging studies pertaining to normal neurocranial development. Here, taking advantage of a large data bank of high quality brain MRI from healthy children ages 0-4 years old, and of a novel conformal geometry-based analysis pipeline, we have been determining a set of statistical atlases of the neurocranium, divided into age groups. In this first part of the study, we focus more specifically on a comparison of 1 and 2 year old infants. Characterizing neurocranium shape changes will enable us to understand how the cranial bones develop in relation to brain development. This in turn will allow a better determination of the effects of neurocranial disorders, which will help inform treatment strategies.

Original languageEnglish (US)
Title of host publication11th International Symposium on Medical Information Processing and Analysis
EditorsJuan D. Garcia-Arteaga, Jorge Brieva, Natasha Lepore, Eduardo Romero
ISBN (Electronic)9781628419160
StatePublished - 2015
Event11th International Symposium on Medical Information Processing and Analysis, SIPAIM 2015 - Cuenca, Ecuador
Duration: Nov 17 2015Nov 19 2015

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X


Other11th International Symposium on Medical Information Processing and Analysis, SIPAIM 2015


  • Neurocranium
  • brain
  • neonatal/pediatric imaging

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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