TY - JOUR
T1 - Cellular, Histologic, and Molecular Changes Associated With Endometriosis and Ovarian Cancer
AU - Siufi Neto, João
AU - Kho, Rosanne M.
AU - dos Santos Siufi, Daniela Freitas
AU - Baracat, Edmund Chada
AU - Anderson, Karen
AU - Abrão, Maurício Simões
PY - 2014/1
Y1 - 2014/1
N2 - Our understanding of the pathogenesis of endometriosis is rapidly evolving as early molecular events are increasingly identified. Endometriosis is associated with increased risk of ovarian cancer and exhibits neoplastic phenotypes including invasion of stromal tissue and lymphatic spread to distant organs. This review of the literature establishes the clinical, epidemiologic, and pathologic correlation between endometriosis and low-grade ovarian cancer. Genetic studies have demonstrated that endometriotic lesions have mutations in genes directly related to neoplasms, in particular the p53, KRAS, PTEN, and ARID1A genes, which suggests a direct transition from a subset of endometriotic lesions to invasive carcinomas. The identification of both genetic and epigenetic biomarkers including microRNAs are essential for identifying patients at risk for the transition to neoplasia.
AB - Our understanding of the pathogenesis of endometriosis is rapidly evolving as early molecular events are increasingly identified. Endometriosis is associated with increased risk of ovarian cancer and exhibits neoplastic phenotypes including invasion of stromal tissue and lymphatic spread to distant organs. This review of the literature establishes the clinical, epidemiologic, and pathologic correlation between endometriosis and low-grade ovarian cancer. Genetic studies have demonstrated that endometriotic lesions have mutations in genes directly related to neoplasms, in particular the p53, KRAS, PTEN, and ARID1A genes, which suggests a direct transition from a subset of endometriotic lesions to invasive carcinomas. The identification of both genetic and epigenetic biomarkers including microRNAs are essential for identifying patients at risk for the transition to neoplasia.
KW - Endometriosis
KW - MicroRNA
KW - Molecular alterations
KW - Ovarian cancer
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U2 - 10.1016/j.jmig.2013.07.021
DO - 10.1016/j.jmig.2013.07.021
M3 - Review article
C2 - 23962574
AN - SCOPUS:84891145065
SN - 1553-4650
VL - 21
SP - 55
EP - 63
JO - Journal of Minimally Invasive Gynecology
JF - Journal of Minimally Invasive Gynecology
IS - 1
ER -