Cell Biology: Functional Conservation, Structural Divergence, and Surprising Convergence in the MICOS Complex of Trypanosomes

Jeremy G. Wideman; Sergio A. Muñoz-Gómez

doi:10.1016/j.cub.2018.09.057

Cell Biology: Functional Conservation, Structural Divergence, and Surprising Convergence in the MICOS Complex of Trypanosomes

Jeremy G. Wideman, Sergio A. Muñoz-Gómez

Research output: Contribution to journal › Short survey › peer-review

5 Scopus citations

Abstract

The MICOS complex is conserved across eukaryotes, but little is known about it outside the group that comprises animals and fungi. A new study finds that mitochondria of trypanosomatid parasites bear a divergent MICOS with both ancestral and derived subunits, but with conserved functions in crista development and membrane contact-site formation. The MICOS complex is conserved across eukaryotes, but little is known about it outside the group that comprises animals and fungi. A new study finds that mitochondria of trypanosomatid parasites bear a divergent MICOS with both ancestral and derived subunits, but with conserved functions in crista development and membrane contact site formation.

Original language	English (US)
Pages (from-to)	R1245-R1248
Journal	Current Biology
Volume	28
Issue number	21
DOIs	https://doi.org/10.1016/j.cub.2018.09.057
State	Published - Nov 5 2018
Externally published	Yes

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)

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abstract = "The MICOS complex is conserved across eukaryotes, but little is known about it outside the group that comprises animals and fungi. A new study finds that mitochondria of trypanosomatid parasites bear a divergent MICOS with both ancestral and derived subunits, but with conserved functions in crista development and membrane contact-site formation. The MICOS complex is conserved across eukaryotes, but little is known about it outside the group that comprises animals and fungi. A new study finds that mitochondria of trypanosomatid parasites bear a divergent MICOS with both ancestral and derived subunits, but with conserved functions in crista development and membrane contact site formation.",

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AB - The MICOS complex is conserved across eukaryotes, but little is known about it outside the group that comprises animals and fungi. A new study finds that mitochondria of trypanosomatid parasites bear a divergent MICOS with both ancestral and derived subunits, but with conserved functions in crista development and membrane contact-site formation. The MICOS complex is conserved across eukaryotes, but little is known about it outside the group that comprises animals and fungi. A new study finds that mitochondria of trypanosomatid parasites bear a divergent MICOS with both ancestral and derived subunits, but with conserved functions in crista development and membrane contact site formation.

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Cell Biology: Functional Conservation, Structural Divergence, and Surprising Convergence in the MICOS Complex of Trypanosomes

Abstract

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