Abstract
Bioassay-guided fractionation of an active methyl ethyl ketone extract of Edgeworthia gardneri, using an assay to monitor DNA polymerase β lyase inhibition, resulted in the isolation of three known biscoumarin derivatives, 7-hydroxy-3,7′-dicoumaryl ether (edgeworin, 1), 7-hydroxy-6-methoxy-3, 7′-dicoumaryl ether (daphnoretin, 2), and 6,7-dihydroxy-3,7′- dicoumaryl ether (edgeworthin, 3). Compounds 1-3 inhibited the lyase activity of DNA polymerase β with IC50 values of 7.3 μg/mL (22.5 μM), 43.0 μg/mL (122.3 μM), and 32.1 μg/mL (94.8 μM), respectively.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1608-1610 |
| Number of pages | 3 |
| Journal | Journal of Natural Products |
| Volume | 67 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 2004 |
| Externally published | Yes |
ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry