Bioerosion of Synthetic Sling Explants

Katherine E. Washington, Gina Quiram, Angela Nguyen, Ruvanthi N. Kularatne, Majid Minary-Jolandan, Philippe Zimmern, Mihaela C. Stefan

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


This study was performed to investigate the changes over time in polypropylene (PP) mesh explants from women with stress urinary incontinence originally treated with a midurethral PP sling. Following Institutional Review Board (IRB) approval, 10 PP explants removed for pain or obstructive symptoms between January and June 2016 were analyzed through various techniques to determine the degradation of the material in vivo. Exclusion criteria were exposed or infected mesh sling or sling in place for less than six months. One pristine control was studied for comparison. The explant samples were analyzed with scanning electron microscopy to visualize the surface defects as well as infrared spectroscopy and energy dispersive X-ray spectroscopy to determine if the degradation was oxidative in nature. The results show qualitative and quantitative bioerosion over the surface of the explant samples and an increase in the content of oxygen pointing toward oxidative degradation occurring in vivo.

Original languageEnglish (US)
Pages (from-to)2598-2605
Number of pages8
JournalACS Biomaterials Science and Engineering
Issue number10
StatePublished - Oct 9 2017
Externally publishedYes


  • oxidative degradation
  • polypropylene
  • sling mesh explant
  • surgical mesh
  • synthetic sling

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering


Dive into the research topics of 'Bioerosion of Synthetic Sling Explants'. Together they form a unique fingerprint.

Cite this