Biocompatible benzocyclobutene-based intracortical neural implant with surface modification

Keekeun Lee, Stephen Massia, Jiping He

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


This paper presents the fabrication of a benzocyclobutene (BCB) polymer-based intracortical neural implant for reliable and stable long-term implant function. BCB polymer has many attractive features for chronic implant application: flexibility, biocompatibility, low moisture uptake, low dielectric constant and easy surface modification. A 2 νm thick silicon backbone layer was attached underneath a flexible BCB electrode to improve mechanical stiffness. No insertion trauma was observed during penetrating into the dura of a rat. In vitro cytotoxicity tests of the completed BCB electrode revealed no toxic effects on cultured cells. The modified BCB surface with a dextran coating showed a significant reduction in 3T3 cell adhesion and spreading, indicating that this coating has the potential for lowering protein adsorption, minimizing inflammatory cell adhesion and glial scar formation in vivo, and thereby enhancing long-term implant performance.

Original languageEnglish (US)
Pages (from-to)2149-2155
Number of pages7
JournalJournal of Micromechanics and Microengineering
Issue number11
StatePublished - Nov 1 2005

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering


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