Association of Cerebrovascular Imaging Biomarkers, Depression, and Anxiety, with Mild Cognitive Impairment

Maria Vassilaki; Jeremy A. Syrjanen; Janina Krell-Roesch; Jonathan Graff-Radford; Prashanthi Vemuri; Eugene L. Scharf; Mary M. MacHulda; Julie A. Fields; Walter K. Kremers; Val J. Lowe; Clifford R. Jack; David S. Knopman; Ronald C. Petersen; Yonas E. Geda

doi:10.3233/ADR-230073

Association of Cerebrovascular Imaging Biomarkers, Depression, and Anxiety, with Mild Cognitive Impairment

Maria Vassilaki
, Jeremy A. Syrjanen
, Janina Krell-Roesch
, Jonathan Graff-Radford
, Prashanthi Vemuri
, Eugene L. Scharf
, Mary M. MacHulda
, Julie A. Fields
, Walter K. Kremers
, Val J. Lowe
, Clifford R. Jack
, David S. Knopman
, Ronald C. Petersen
, Yonas E. Geda

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The study included 1,738 Mayo Clinic Study of Aging participants (≥50 years old; 1,460 cognitively unimpaired and 278 with mild cognitive impairment (MCI)) and examined the cross-sectional association between cerebrovascular (CVD) imaging biomarkers (e.g., white matter hyperintensities (WMH), infarctions) and Beck Depression Inventory-II (BDI-II) and Beck Anxiety Inventory (BAI) scores, as well as their association with MCI. High (abnormal) WMH burden was significantly associated with having BDI-II>13 and BAI > 7 scores, and both (CVD imaging biomarkers and depression/anxiety) were significantly associated with MCI when included simultaneously in the model, suggesting that both were independently associated with the odds of MCI.

Original language	English (US)
Pages (from-to)	1237-1246
Number of pages	10
Journal	Journal of Alzheimer's Disease Reports
Volume	7
Issue number	1
DOIs	https://doi.org/10.3233/ADR-230073
State	Published - Nov 3 2023
Externally published	Yes

Keywords

Alzheimer's disease
anxiety
cerebrovascular
depression
mild cognitive impairment
neuroimaging

ASJC Scopus subject areas

General Neuroscience
Clinical Psychology
Geriatrics and Gerontology
Psychiatry and Mental health

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10.3233/ADR-230073

Cite this

Vassilaki, M., Syrjanen, J. A., Krell-Roesch, J., Graff-Radford, J., Vemuri, P., Scharf, E. L., MacHulda, M. M., Fields, J. A., Kremers, W. K., Lowe, V. J., Jack, C. R., Knopman, D. S., Petersen, R. C., & Geda, Y. E. (2023). Association of Cerebrovascular Imaging Biomarkers, Depression, and Anxiety, with Mild Cognitive Impairment. Journal of Alzheimer's Disease Reports, 7(1), 1237-1246. https://doi.org/10.3233/ADR-230073

Vassilaki, M, Syrjanen, JA, Krell-Roesch, J, Graff-Radford, J, Vemuri, P, Scharf, EL, MacHulda, MM, Fields, JA, Kremers, WK, Lowe, VJ, Jack, CR, Knopman, DS, Petersen, RC & Geda, YE 2023, 'Association of Cerebrovascular Imaging Biomarkers, Depression, and Anxiety, with Mild Cognitive Impairment', Journal of Alzheimer's Disease Reports, vol. 7, no. 1, pp. 1237-1246. https://doi.org/10.3233/ADR-230073

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title = "Association of Cerebrovascular Imaging Biomarkers, Depression, and Anxiety, with Mild Cognitive Impairment",

abstract = "The study included 1,738 Mayo Clinic Study of Aging participants (≥50 years old; 1,460 cognitively unimpaired and 278 with mild cognitive impairment (MCI)) and examined the cross-sectional association between cerebrovascular (CVD) imaging biomarkers (e.g., white matter hyperintensities (WMH), infarctions) and Beck Depression Inventory-II (BDI-II) and Beck Anxiety Inventory (BAI) scores, as well as their association with MCI. High (abnormal) WMH burden was significantly associated with having BDI-II>13 and BAI > 7 scores, and both (CVD imaging biomarkers and depression/anxiety) were significantly associated with MCI when included simultaneously in the model, suggesting that both were independently associated with the odds of MCI.",

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author = "Maria Vassilaki and Syrjanen, \{Jeremy A.\} and Janina Krell-Roesch and Jonathan Graff-Radford and Prashanthi Vemuri and Scharf, \{Eugene L.\} and MacHulda, \{Mary M.\} and Fields, \{Julie A.\} and Kremers, \{Walter K.\} and Lowe, \{Val J.\} and Jack, \{Clifford R.\} and Knopman, \{David S.\} and Petersen, \{Ronald C.\} and Geda, \{Yonas E.\}",

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doi = "10.3233/ADR-230073",

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AU - MacHulda, Mary M.

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AB - The study included 1,738 Mayo Clinic Study of Aging participants (≥50 years old; 1,460 cognitively unimpaired and 278 with mild cognitive impairment (MCI)) and examined the cross-sectional association between cerebrovascular (CVD) imaging biomarkers (e.g., white matter hyperintensities (WMH), infarctions) and Beck Depression Inventory-II (BDI-II) and Beck Anxiety Inventory (BAI) scores, as well as their association with MCI. High (abnormal) WMH burden was significantly associated with having BDI-II>13 and BAI > 7 scores, and both (CVD imaging biomarkers and depression/anxiety) were significantly associated with MCI when included simultaneously in the model, suggesting that both were independently associated with the odds of MCI.

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Association of Cerebrovascular Imaging Biomarkers, Depression, and Anxiety, with Mild Cognitive Impairment

Abstract

Keywords

ASJC Scopus subject areas

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