Abstract
Introduction: To examine whether within-person changes in total, regional and organ fat were associated with within-person changes in type 2 diabetes (T2D)-related biomarkers following interventions. Methods: A secondary analysis from a randomised trial among Latino youth (30 males, 25 females) aged 12–16 years with obesity. The study sample combined participants randomised to either lifestyle intervention (N = 39) or usual care (N = 16). Total body composition was assessed by DEXA. Hepatic and pancreatic fat fractions were assessed using MRI. T2D risk factors included insulin sensitivity, beta-cell function and post-challenge glucose. Results: Significant changes in %body fat, lean mass, insulin sensitivity and 2-h glucose were observed. Changes in fat mass were associated with changes in insulin sensitivity (β = −0.45, p < 0.001), while changes in lean mass were associated with changes in 2-h glucose concentrations (β = −0.50, p = 0.02). No association between changes in total, regional, or organ fat and beta cell function were noted. Conclusions: Our study revealed that within-person changes in fat mass and lean mass were associated with increased insulin sensitivity and reduced 2-h glucose concentrations, respectively, among high-risk Latino youth. The impact of reductions in regional and organ fat deposition on T2D risk factors warrants further examination.
Original language | English (US) |
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Article number | e13185 |
Journal | Pediatric Obesity |
Volume | 20 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2025 |
Keywords
- beta cell function
- ectopic fat
- insulin resistance
- obesity
- paediatrics
- type 2 diabetes
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Health Policy
- Nutrition and Dietetics
- Public Health, Environmental and Occupational Health