Antineoplastic agents, 99. amaryllis belladonna

George Pettit; Venkatswamy Gaddamidi; Animesh Goswami; Gordon M. Cragg

doi:10.1021/np50035a007

Antineoplastic agents, 99. amaryllis belladonna

George Pettit, Venkatswamy Gaddamidi, Animesh Goswami, Gordon M. Cragg

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

Amaryllis belladonna bulbs were examined for constiuents inhibitory against the murine P-388 lymphocytic leukemia (PS system). Two in vitro active alkaloids, acetylcaranine (2; 9PS ED₅₀0.23 μg/ml) and ambelline (3; 9PS ED₅₀1.6 μg/ml), were isolated accompanied by undulatine. However, the non-chi ral anhydrolycorinium chloride (5) was found to be the principal antineoplastic (3 PS, 64-69% life extension at dose levels 10 to 20 mg/kg in vivo, ED₅₀1.4 μg/ml in vitro) component. Quaternary chloride 5 has not been located previously among plant or animal biosynthetic products.

Original language	English (US)
Pages (from-to)	796-801
Number of pages	6
Journal	Journal of Natural Products
Volume	47
Issue number	5
DOIs	https://doi.org/10.1021/np50035a007
State	Published - Oct 1984

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np50035a007

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title = "Antineoplastic agents, 99. amaryllis belladonna",

abstract = "Amaryllis belladonna bulbs were examined for constiuents inhibitory against the murine P-388 lymphocytic leukemia (PS system). Two in vitro active alkaloids, acetylcaranine (2; 9PS ED500.23 μg/ml) and ambelline (3; 9PS ED501.6 μg/ml), were isolated accompanied by undulatine. However, the non-chi ral anhydrolycorinium chloride (5) was found to be the principal antineoplastic (3 PS, 64-69% life extension at dose levels 10 to 20 mg/kg in vivo, ED501.4 μg/ml in vitro) component. Quaternary chloride 5 has not been located previously among plant or animal biosynthetic products.",

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T1 - Antineoplastic agents, 99. amaryllis belladonna

AU - Pettit, George

AU - Gaddamidi, Venkatswamy

AU - Goswami, Animesh

AU - Cragg, Gordon M.

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N2 - Amaryllis belladonna bulbs were examined for constiuents inhibitory against the murine P-388 lymphocytic leukemia (PS system). Two in vitro active alkaloids, acetylcaranine (2; 9PS ED500.23 μg/ml) and ambelline (3; 9PS ED501.6 μg/ml), were isolated accompanied by undulatine. However, the non-chi ral anhydrolycorinium chloride (5) was found to be the principal antineoplastic (3 PS, 64-69% life extension at dose levels 10 to 20 mg/kg in vivo, ED501.4 μg/ml in vitro) component. Quaternary chloride 5 has not been located previously among plant or animal biosynthetic products.

AB - Amaryllis belladonna bulbs were examined for constiuents inhibitory against the murine P-388 lymphocytic leukemia (PS system). Two in vitro active alkaloids, acetylcaranine (2; 9PS ED500.23 μg/ml) and ambelline (3; 9PS ED501.6 μg/ml), were isolated accompanied by undulatine. However, the non-chi ral anhydrolycorinium chloride (5) was found to be the principal antineoplastic (3 PS, 64-69% life extension at dose levels 10 to 20 mg/kg in vivo, ED501.4 μg/ml in vitro) component. Quaternary chloride 5 has not been located previously among plant or animal biosynthetic products.

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Antineoplastic agents, 99. amaryllis belladonna

Abstract

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