Antineoplastic agents. 67. senecio fendleri gray

George Pettit, James J. Einck, Peter Brown, Thomas B. Harvey, Richard H. Ode, Charles P. Pase

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


A prominent anticancer constituent of the subalpine Rocky Mountain plant Senecio fendleri Gray was found to be the ethyl ester counterpart (1a) of Jacaranone. The structure of ethyl α-[4-(4-hydroxy-cyclohexa-2,5-dien-1-one)]-acetate (1a) was established by spectral (principally nuclear magnetic resonance and mass spectrometry) analysis and transformation to azobenzene 3. An x-ray crystal structure determination of the latter substance (3) confirmed the overall assignments.

Original languageEnglish (US)
Pages (from-to)609-616
Number of pages8
JournalJournal of Natural Products
Issue number5
StatePublished - Sep 1980

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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