Antineoplastic agents 596. Isolation and structure of chromomycin A5 from a Beaufort Sea microorganism

George Pettit; Rui Tan; Robin Pettit; Dennis L. Doubek; Jean Chapuis; Christine A. Weber

doi:10.1039/c4ra16517a

Antineoplastic agents 596. Isolation and structure of chromomycin A₅ from a Beaufort Sea microorganism

George Pettit, Rui Tan, Robin Pettit, Dennis L. Doubek, Jean Chapuis, Christine A. Weber

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5 Scopus citations

Abstract

A microorganism identified as Streptomyces sp. was isolated from a sedimentary specimen collected on the Beaufort Sea coast of Alaska. Fermentation scale-up and cancer cell line-guided separation of the constituents led to isolation and structural elucidation (high resolution MALDI-TOF mass and 2D NMR spectral analyses) of a diastereomer of chromomycin A2 (2) designated chromomycin A₅ (5). Chromomycin A₅ displayed very potent cancer cell growth inhibitory activity (reaching with MCF-7 breast cancer GI₅₀ 0.00073 μg mL^-1) against a mini-panel of murine and human cancer cell lines.

Original language	English (US)
Pages (from-to)	9116-9122
Number of pages	7
Journal	RSC Advances
Volume	5
Issue number	12
DOIs	https://doi.org/10.1039/c4ra16517a
State	Published - 2015

ASJC Scopus subject areas

Chemistry(all)
Chemical Engineering(all)

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abstract = "A microorganism identified as Streptomyces sp. was isolated from a sedimentary specimen collected on the Beaufort Sea coast of Alaska. Fermentation scale-up and cancer cell line-guided separation of the constituents led to isolation and structural elucidation (high resolution MALDI-TOF mass and 2D NMR spectral analyses) of a diastereomer of chromomycin A2 (2) designated chromomycin A5 (5). Chromomycin A5 displayed very potent cancer cell growth inhibitory activity (reaching with MCF-7 breast cancer GI50 0.00073 μg mL-1) against a mini-panel of murine and human cancer cell lines.",

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AU - Pettit, George

AU - Tan, Rui

AU - Pettit, Robin

AU - Doubek, Dennis L.

AU - Chapuis, Jean

AU - Weber, Christine A.

PY - 2015

Y1 - 2015

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Antineoplastic agents 596. Isolation and structure of chromomycin A₅ from a Beaufort Sea microorganism

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