Antineoplastic Agents. 55. Isolation and Structure of Multigilin and Multistatin

George Pettit; Cherry L. Herald; Devens Gust; Delbert L. Herald; Lawrence D. Vanell

doi:10.1021/jo00400a015

Antineoplastic Agents. 55. Isolation and Structure of Multigilin and Multistatin

George Pettit, Cherry L. Herald, Devens Gust, Delbert L. Herald, Lawrence D. Vanell

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18 Scopus citations

Abstract

Two new cytotoxic and antineoplastic pseudoguaianolides designated multigilin (2b) and multistatin (2d) have been isolated from Baileya multiradiata Harv. and Gray. The related sesquiterpene lactone fastigilin A (lc) was also found to be a constituent of this plant. With the x-ray crystal structure of radiatin (1a) serving as a valuable reference, complete structural and stereochemical assignments were made for fastigilin A (lc), multigilin (2b), and multistatin (2d). Interpretation of the 13C nuclear magnetic resonance spectra provided a firm basis for these assignments and allowed further confirmation of structures previously proposed for fastigilin B (lb), fastigilin C (2a), and multiradiatin (2c).

Original language	English (US)
Pages (from-to)	1092-1095
Number of pages	4
Journal	Journal of Organic Chemistry
Volume	43
Issue number	6
DOIs	https://doi.org/10.1021/jo00400a015
State	Published - 1978

ASJC Scopus subject areas

Organic Chemistry

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title = "Antineoplastic Agents. 55. Isolation and Structure of Multigilin and Multistatin",

abstract = "Two new cytotoxic and antineoplastic pseudoguaianolides designated multigilin (2b) and multistatin (2d) have been isolated from Baileya multiradiata Harv. and Gray. The related sesquiterpene lactone fastigilin A (lc) was also found to be a constituent of this plant. With the x-ray crystal structure of radiatin (1a) serving as a valuable reference, complete structural and stereochemical assignments were made for fastigilin A (lc), multigilin (2b), and multistatin (2d). Interpretation of the 13C nuclear magnetic resonance spectra provided a firm basis for these assignments and allowed further confirmation of structures previously proposed for fastigilin B (lb), fastigilin C (2a), and multiradiatin (2c).",

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journal = "Journal of Organic Chemistry",

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T1 - Antineoplastic Agents. 55. Isolation and Structure of Multigilin and Multistatin

AU - Pettit, George

AU - Herald, Cherry L.

AU - Gust, Devens

AU - Herald, Delbert L.

AU - Vanell, Lawrence D.

PY - 1978

Y1 - 1978

N2 - Two new cytotoxic and antineoplastic pseudoguaianolides designated multigilin (2b) and multistatin (2d) have been isolated from Baileya multiradiata Harv. and Gray. The related sesquiterpene lactone fastigilin A (lc) was also found to be a constituent of this plant. With the x-ray crystal structure of radiatin (1a) serving as a valuable reference, complete structural and stereochemical assignments were made for fastigilin A (lc), multigilin (2b), and multistatin (2d). Interpretation of the 13C nuclear magnetic resonance spectra provided a firm basis for these assignments and allowed further confirmation of structures previously proposed for fastigilin B (lb), fastigilin C (2a), and multiradiatin (2c).

AB - Two new cytotoxic and antineoplastic pseudoguaianolides designated multigilin (2b) and multistatin (2d) have been isolated from Baileya multiradiata Harv. and Gray. The related sesquiterpene lactone fastigilin A (lc) was also found to be a constituent of this plant. With the x-ray crystal structure of radiatin (1a) serving as a valuable reference, complete structural and stereochemical assignments were made for fastigilin A (lc), multigilin (2b), and multistatin (2d). Interpretation of the 13C nuclear magnetic resonance spectra provided a firm basis for these assignments and allowed further confirmation of structures previously proposed for fastigilin B (lb), fastigilin C (2a), and multiradiatin (2c).

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Antineoplastic Agents. 55. Isolation and Structure of Multigilin and Multistatin

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