Antineoplastic Agents. 520. Isolation and Structure of Irciniastatins A and B from the Indo-Pacific Marine Sponge Ircinia ramosa

George Pettit; Jun-Ping Xu; Jean Chapuis; Robin Pettit; Larry P. Tackett; Dennis L. Doubek; John N A Hooper; Jean M. Schmidt

doi:10.1021/jm030207d

Antineoplastic Agents. 520. Isolation and Structure of Irciniastatins A and B from the Indo-Pacific Marine Sponge Ircinia ramosa

George Pettit, Jun-Ping Xu, Jean Chapuis, Robin Pettit, Larry P. Tackett, Dennis L. Doubek, John N A Hooper, Jean M. Schmidt

Research output: Contribution to journal › Article › peer-review

133 Scopus citations

Abstract

The Indo-Pacific marine sponge Ircinia ramosa has been found to contain two powerful (GI₅₀ from 0.001 to <0.0001 μg/mL) murine and human cancer cell growth inhibitors. Both were isolated (10^-3-10 ^-4% yields) by cancer cell line bioassay-guided techniques and named irciniastatins A (1) and B (2). Structural elucidation by a combination of spectral analyses, primarily high resolution mass and 2D-NMR (principally APT, HMQC, HMBC, and ROESY) spectroscopy, revealed the unusual structures 1 and 2.

Original language	English (US)
Pages (from-to)	1149-1152
Number of pages	4
Journal	Journal of Medicinal Chemistry
Volume	47
Issue number	5
DOIs	https://doi.org/10.1021/jm030207d
State	Published - Feb 26 2004

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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AU - Xu, Jun-Ping

AU - Chapuis, Jean

AU - Pettit, Robin

AU - Tackett, Larry P.

AU - Doubek, Dennis L.

AU - Hooper, John N A

AU - Schmidt, Jean M.

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AB - The Indo-Pacific marine sponge Ircinia ramosa has been found to contain two powerful (GI50 from 0.001 to <0.0001 μg/mL) murine and human cancer cell growth inhibitors. Both were isolated (10-3-10 -4% yields) by cancer cell line bioassay-guided techniques and named irciniastatins A (1) and B (2). Structural elucidation by a combination of spectral analyses, primarily high resolution mass and 2D-NMR (principally APT, HMQC, HMBC, and ROESY) spectroscopy, revealed the unusual structures 1 and 2.

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Antineoplastic Agents. 520. Isolation and Structure of Irciniastatins A and B from the Indo-Pacific Marine Sponge Ircinia ramosa

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