Antineoplastic agents, 107. Isolation of acteoside and isoacteoside from castilleja linariaefolia

George Pettit; Atsushi Numata; Tsuruko Takemura; Richard H. Ode; A. S. Narula; Jean M. Schmidt; Gordon M. Cragg; Charles P. Pase

doi:10.1021/np50068a026

Antineoplastic agents, 107. Isolation of acteoside and isoacteoside from castilleja linariaefolia

George Pettit
, Atsushi Numata
, Tsuruko Takemura
, Richard H. Ode
, A. S. Narula
, Jean M. Schmidt
, Gordon M. Cragg
, Charles P. Pase

Research output: Contribution to journal › Article › peer-review

89 Scopus citations

Abstract

The southwestern Indian paintbrush, Castilltja linariaefolia, yielded extracts that displayed in vivo activity against murine P-388 (PS) lymphocytic leukemia. Separation guided by PS cell line inhibition led to isolation of cytotoxic compounds that were identified as the known glycosides acteoside [1] (ED₅₀ 2.6 μg/ml) and isoacteoside [2] (ED₅₀ 10 μg/ml). The identifications were established by spectral measurements and degradation studies. Mannitol was also found in this plant.

Original language	English (US)
Pages (from-to)	456-458
Number of pages	3
Journal	Journal of Natural Products
Volume	53
Issue number	2
DOIs	https://doi.org/10.1021/np50068a026
State	Published - 1990

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np50068a026

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title = "Antineoplastic agents, 107. Isolation of acteoside and isoacteoside from castilleja linariaefolia",

abstract = "The southwestern Indian paintbrush, Castilltja linariaefolia, yielded extracts that displayed in vivo activity against murine P-388 (PS) lymphocytic leukemia. Separation guided by PS cell line inhibition led to isolation of cytotoxic compounds that were identified as the known glycosides acteoside [1] (ED50 2.6 μg/ml) and isoacteoside [2] (ED50 10 μg/ml). The identifications were established by spectral measurements and degradation studies. Mannitol was also found in this plant.",

author = "George Pettit and Atsushi Numata and Tsuruko Takemura and Ode, \{Richard H.\} and Narula, \{A. S.\} and Schmidt, \{Jean M.\} and Cragg, \{Gordon M.\} and Pase, \{Charles P.\}",

year = "1990",

doi = "10.1021/np50068a026",

language = "English (US)",

volume = "53",

pages = "456--458",

journal = "Journal of Natural Products",

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T1 - Antineoplastic agents, 107. Isolation of acteoside and isoacteoside from castilleja linariaefolia

AU - Pettit, George

AU - Numata, Atsushi

AU - Takemura, Tsuruko

AU - Ode, Richard H.

AU - Narula, A. S.

AU - Schmidt, Jean M.

AU - Cragg, Gordon M.

AU - Pase, Charles P.

PY - 1990

Y1 - 1990

N2 - The southwestern Indian paintbrush, Castilltja linariaefolia, yielded extracts that displayed in vivo activity against murine P-388 (PS) lymphocytic leukemia. Separation guided by PS cell line inhibition led to isolation of cytotoxic compounds that were identified as the known glycosides acteoside [1] (ED50 2.6 μg/ml) and isoacteoside [2] (ED50 10 μg/ml). The identifications were established by spectral measurements and degradation studies. Mannitol was also found in this plant.

AB - The southwestern Indian paintbrush, Castilltja linariaefolia, yielded extracts that displayed in vivo activity against murine P-388 (PS) lymphocytic leukemia. Separation guided by PS cell line inhibition led to isolation of cytotoxic compounds that were identified as the known glycosides acteoside [1] (ED50 2.6 μg/ml) and isoacteoside [2] (ED50 10 μg/ml). The identifications were established by spectral measurements and degradation studies. Mannitol was also found in this plant.

UR - https://www.scopus.com/pages/publications/0025358099

UR - https://www.scopus.com/pages/publications/0025358099#tab=citedBy

U2 - 10.1021/np50068a026

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AN - SCOPUS:0025358099

SN - 0163-3864

VL - 53

SP - 456

EP - 458

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 2

ER -

Antineoplastic agents, 107. Isolation of acteoside and isoacteoside from castilleja linariaefolia

Abstract

ASJC Scopus subject areas

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