Antibacterial activity of the marine sponge constituent cribrostatin 6

Robin Pettit, Bridget R. Fakoury, John C. Knight, Christine A. Weber, George Pettit, Gary D. Cage, Sandy Pon

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


The antibacterial activity of the nitrogen heterocyclic sponge constituent cribrostatin 6 was examined. Cribrostatin 6 was bacteriostatic for a variety of Gram-positive species and was bactericidal for the majority of clinical isolates of Streptococcus pneumoniae, including penicillin-resistant strains. Minimum bactericidal concentration/MIC ratios were ≤2 for 75 % of S. pneumoniae clinical isolates. Kill-curve analysis confirmed the bactericidal action of cribrostatin 6. Bactericidal activity was rather slow, beginning at 2, 4 or 8 h, depending on the strain. The frequency of occurrence of bacterial spontaneous mutations to resistance was ≤10-7. The maximum tolerated dose of cribrostatin 6 in mice was 750-1000 μg kg-1 day-1. Cribrostatin 6 is a promising lead antibiotic for Gram-positive bacteria, particularly S. pneumoniae, a leading cause of infection and mortality worldwide.

Original languageEnglish (US)
Pages (from-to)61-65
Number of pages5
JournalJournal of Medical Microbiology
Issue number1
StatePublished - Jan 2004

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)


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