An efficient synthesis of daidzein, dimethyldaidzein, and isoformononetin

Kyle F. Biegasiewicz, Jeffrey D.St Denis, Vincent M. Carroll, Ronny Priefer

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Synthesis of the soy isoflavone, daidzein, and its derivatives, isoformononetin and dimethyldaidzein, through utilization of a novel synthetic pathway is reported. This synthesis employs an enamine addition and O-methylation of 2,4-dihydroxyacetophenone, a subsequent ring closure and iodination, followed by a Suzuki coupling with PEG 10000. Demethylation of either isoformononetin or dimethyldaidzein afforded daidzein.

Original languageEnglish (US)
Pages (from-to)4408-4410
Number of pages3
JournalTetrahedron Letters
Issue number33
StatePublished - Aug 18 2010
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


Dive into the research topics of 'An efficient synthesis of daidzein, dimethyldaidzein, and isoformononetin'. Together they form a unique fingerprint.

Cite this