Abstract
Background: VopS is a bacterial effector that AMPylates Rho GTPases.
Results: AMPylation of Rho GTPases inhibits their interaction with multiple downstream effectors.
Conclusion: VopS conducts a multifaceted host signaling inhibition program by targeting the critical Rho GTPases.
Significance: Broadens the understanding of how switch-1 modification of Rho GTPases affects host responses.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 32977-32988 |
| Number of pages | 12 |
| Journal | Journal of Biological Chemistry |
| Volume | 289 |
| Issue number | 47 |
| DOIs | |
| State | Published - Nov 21 2014 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology
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