Acute reserpine administration elicits long-term spontaneous oral dyskinesia

Amy N. Sussman, Ly T L Tran-Nguyen, Janet Neisewander

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Chronic reserpine administration produces persistent oral dyskinesia accompanied by severe dopamine depletion in the caudate-putamen. The present study examined whether these behavioral and neurochemical effects would persist following acute reserpine administration. Acute administration of reserpine (1 mg/kg, s.c.) produced spontaneous oral dyskinesia that persisted above control levels for at least 84 days. Reserpine also produced a 74% depletion of dopamine in the caudate-putamen relative to vehicle treatment at 3 days post-injection, but did not significantly alter dopamine in the caudate-putamen at 84 days post-injection. The finding that reserpine-induced oral dyskinesia persisted despite repletion of dopamine in the caudate-putamen suggests that the persistent neuropathological change underlying this behavior occurs in a neural pathway other than the dopaminergic nigrostriatal pathway.

Original languageEnglish (US)
Pages (from-to)157-160
Number of pages4
JournalEuropean Journal of Pharmacology
Issue number2-3
StatePublished - Oct 22 1997


  • Dopamine
  • Oral dyskinesia
  • Reserpine
  • Tardive dyskinesia
  • Tongue protrusion

ASJC Scopus subject areas

  • Pharmacology


Dive into the research topics of 'Acute reserpine administration elicits long-term spontaneous oral dyskinesia'. Together they form a unique fingerprint.

Cite this