Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-δ accelerates intestinal adenoma growth

Rajnish A. Gupta; Dingzhi Wang; Sharada Katkuri; Haibin Wang; Sudhansu K. Dey; Raymond N. DuBois

doi:10.1038/nm993

Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-δ accelerates intestinal adenoma growth

Rajnish A. Gupta, Dingzhi Wang, Sharada Katkuri, Haibin Wang, Sudhansu K. Dey, Raymond N. DuBois

Biodesign Institute

Research output: Contribution to journal › Article › peer-review

256 Scopus citations

Abstract

We treated Apc^min mice, which are predisposed to intestinal polyposis, with a selective synthetic agonist of peroxisome proliferator-activated receptor-δ (PPAR-δ). Exposure of Apcrnin mice to the PPAR-δ ligand GW501516 resulted in a significant increase in the number and size of intestinal polyps. The most prominent effect was on polyp size; mice treated with the PPAR-δ activator had a fivefold increase in the number of polyps larger than 2 mm. Our results implicate PPAR-δ in the regulation of intestinal adenoma growth.

Original language	English (US)
Pages (from-to)	245-247
Number of pages	3
Journal	Nature Medicine
Volume	10
Issue number	3
DOIs	https://doi.org/10.1038/nm993
State	Published - Mar 2004

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1038/nm993

Cite this

@article{d5ffc90d31ed4d21be3023039e68ed1c,

title = "Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-δ accelerates intestinal adenoma growth",

abstract = "We treated Apcmin mice, which are predisposed to intestinal polyposis, with a selective synthetic agonist of peroxisome proliferator-activated receptor-δ (PPAR-δ). Exposure of Apcrnin mice to the PPAR-δ ligand GW501516 resulted in a significant increase in the number and size of intestinal polyps. The most prominent effect was on polyp size; mice treated with the PPAR-δ activator had a fivefold increase in the number of polyps larger than 2 mm. Our results implicate PPAR-δ in the regulation of intestinal adenoma growth.",

author = "Gupta, {Rajnish A.} and Dingzhi Wang and Sharada Katkuri and Haibin Wang and Dey, {Sudhansu K.} and DuBois, {Raymond N.}",

year = "2004",

month = mar,

doi = "10.1038/nm993",

language = "English (US)",

volume = "10",

pages = "245--247",

journal = "Nature Medicine",

issn = "1078-8956",

publisher = "Nature Publishing Group",

number = "3",

}

TY - JOUR

T1 - Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-δ accelerates intestinal adenoma growth

AU - Gupta, Rajnish A.

AU - Wang, Dingzhi

AU - Katkuri, Sharada

AU - Wang, Haibin

AU - Dey, Sudhansu K.

AU - DuBois, Raymond N.

PY - 2004/3

Y1 - 2004/3

N2 - We treated Apcmin mice, which are predisposed to intestinal polyposis, with a selective synthetic agonist of peroxisome proliferator-activated receptor-δ (PPAR-δ). Exposure of Apcrnin mice to the PPAR-δ ligand GW501516 resulted in a significant increase in the number and size of intestinal polyps. The most prominent effect was on polyp size; mice treated with the PPAR-δ activator had a fivefold increase in the number of polyps larger than 2 mm. Our results implicate PPAR-δ in the regulation of intestinal adenoma growth.

AB - We treated Apcmin mice, which are predisposed to intestinal polyposis, with a selective synthetic agonist of peroxisome proliferator-activated receptor-δ (PPAR-δ). Exposure of Apcrnin mice to the PPAR-δ ligand GW501516 resulted in a significant increase in the number and size of intestinal polyps. The most prominent effect was on polyp size; mice treated with the PPAR-δ activator had a fivefold increase in the number of polyps larger than 2 mm. Our results implicate PPAR-δ in the regulation of intestinal adenoma growth.

UR - http://www.scopus.com/inward/record.url?scp=1942470331&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1942470331&partnerID=8YFLogxK

U2 - 10.1038/nm993

DO - 10.1038/nm993

M3 - Article

C2 - 14758356

AN - SCOPUS:1942470331

SN - 1078-8956

VL - 10

SP - 245

EP - 247

JO - Nature Medicine

JF - Nature Medicine

IS - 3

ER -

Activation of nuclear hormone receptor peroxisome proliferator-activated receptor-δ accelerates intestinal adenoma growth

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this