A unidirectional DNA walker that moves autonomously along a track

Peng Yin, Hao Yan, Xiaoju G. Daniell, Andrew J. Turberfield, John H. Reif

Research output: Contribution to journalArticlepeer-review

415 Scopus citations


There's no turning back for an autonomous DNA walker that moves along a self-assembled track, driven by the hydrolysis of ATP. The track contains three anchorages (A, B, C) at which the walker (*), a six-nucleotide DNA fragment, can be bound (see figure). The motion of the walker is unidirectional. At each step it is ligated to the next anchorage, then cut from the previous one by a restriction endonuclease.

Original languageEnglish (US)
Pages (from-to)4906-4911
Number of pages6
JournalAngewandte Chemie - International Edition
Issue number37
StatePublished - Sep 20 2004
Externally publishedYes


  • DNA
  • Molecular devices
  • Nanorobotics
  • Nanostructures
  • Self-assembly

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


Dive into the research topics of 'A unidirectional DNA walker that moves autonomously along a track'. Together they form a unique fingerprint.

Cite this