A two-strain tuberculosis model with age of infection

Z. Feng, M. Iannelli, F. A. Milner

Research output: Contribution to journalArticlepeer-review

94 Scopus citations


Long periods of latency and the emergence of antibiotic resistance due to incomplete treatment are very important features of tuberculosis (TB) dynamics. Previous studies of two-strain TB have been performed by ODE models. In this article, we formulate a two-strain TB model with an arbitrarily distributed delay in the latent stage of individuals infected with the drug-sensitive strain and look at the effects of variable periods of latency on the disease dynamics.

Original languageEnglish (US)
Pages (from-to)1634-1656
Number of pages23
JournalSIAM Journal on Applied Mathematics
Issue number5
StatePublished - May 2002
Externally publishedYes


  • Distributed delays
  • Mathematical models
  • Stability
  • Tuberculosis

ASJC Scopus subject areas

  • Applied Mathematics


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