A short version of a HRQoL questionnaire for Italian and Japanese patients with Primary Biliary Cirrhosis

Lorenzo Montali, Atsushi Tanaka, Paolo Riva, Hiroki Takahashi, Claudio Cocchi, Yoshiyuki Ueno, Massimo Miglioretti, Hajime Takikawa, Luca Vecchio, Alessandra Frigerio, Ilaria Bianchi, Roberta Jorgensen, Keith D. Lindor, Mauro Podda, Pietro Invernizzi

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Background: The available self-report questionnaire for the quality of life in patients with primary biliary cirrhosis (PBC-40) is currently validated only in the British population but it lacks an evaluation of its dimensionality. Aims: To validate the Italian and Japanese versions of PBC-40 and to assess the dimensionality of the original structure of PBC-40 by a confirmatory factor analysis. PBC-40 was translated to Italian and Japanese using the forward-backward method and then reviewed in focus groups in the framework of a large multicentric study. Methods: A sample of 290 patients with PBC (125 Italian and 165 Japanese) was administered two questionnaires previously validated for PBC-specific (PBC-40) and general quality of life (SF-36). Results: The confirmatory model failed to fit adequately the original hypothesized structure. A principal component analysis led to a seven-factor structure, with exclusion of 13 items characterized by lower load; PBC-27 questionnaire was the final instrument. The validity of the PBC-27 was supported by its strong correlation with the SF-36 scores. Conclusion: We here propose an alternative structure of the quality of life questionnaire for PBC, namely PBC-27, which appears to be effective in detecting the impact of PBC on quality of life in Italian and Japanese patients.

Original languageEnglish (US)
Pages (from-to)718-723
Number of pages6
JournalDigestive and Liver Disease
Issue number10
StatePublished - Oct 2010
Externally publishedYes


  • Factor structure
  • PBC-40
  • Principal component analysis
  • Quality of life

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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