A High-performance nanobio photocatalyst for targeted brain cancer therapy

Elena A. Rozhkova; Ilya Ulasov; Barry Lai; Nada M. Dimitrijevic; Maciej S. Lesniak; Tijana Rajh

doi:10.1021/nl901610f

A High-performance nanobio photocatalyst for targeted brain cancer therapy

Elena A. Rozhkova, Ilya Ulasov, Barry Lai, Nada M. Dimitrijevic, Maciej S. Lesniak, Tijana Rajh

Research output: Contribution to journal › Article › peer-review

258 Scopus citations

Abstract

We report pronounced and specific antiglioblastoma cell phototoxicity of 5 nm TiO₂ particles covalently tethered to an antibody via a dihydroxybenzene bivalent linker. The linker application enables absorption of a visible part of the solar spectrum by the nanobio hybrid. The phototoxicity is mediated by reactive oxygen species (ROS) that initiate programmed death of the cancer cell. Synchrotron X-ray fluorescence microscopy (XFM) was applied for direct visualization of the nanobioconjugate distribution through a single brain cancer cell at the submicrometer scale.

Original language	English (US)
Pages (from-to)	3337-3342
Number of pages	6
Journal	Nano Letters
Volume	9
Issue number	9
DOIs	https://doi.org/10.1021/nl901610f
State	Published - Sep 9 2009
Externally published	Yes

ASJC Scopus subject areas

Bioengineering
Chemistry(all)
Materials Science(all)
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl901610f

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abstract = "We report pronounced and specific antiglioblastoma cell phototoxicity of 5 nm TiO2 particles covalently tethered to an antibody via a dihydroxybenzene bivalent linker. The linker application enables absorption of a visible part of the solar spectrum by the nanobio hybrid. The phototoxicity is mediated by reactive oxygen species (ROS) that initiate programmed death of the cancer cell. Synchrotron X-ray fluorescence microscopy (XFM) was applied for direct visualization of the nanobioconjugate distribution through a single brain cancer cell at the submicrometer scale.",

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AU - Lai, Barry

AU - Dimitrijevic, Nada M.

AU - Lesniak, Maciej S.

AU - Rajh, Tijana

PY - 2009/9/9

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AB - We report pronounced and specific antiglioblastoma cell phototoxicity of 5 nm TiO2 particles covalently tethered to an antibody via a dihydroxybenzene bivalent linker. The linker application enables absorption of a visible part of the solar spectrum by the nanobio hybrid. The phototoxicity is mediated by reactive oxygen species (ROS) that initiate programmed death of the cancer cell. Synchrotron X-ray fluorescence microscopy (XFM) was applied for direct visualization of the nanobioconjugate distribution through a single brain cancer cell at the submicrometer scale.

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A High-performance nanobio photocatalyst for targeted brain cancer therapy

Abstract

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