A feedback control systems view of epileptic seizures

Konstantinos Tsakalis, N. Chakravarthy, Sh Sabesan, L. D. Iasemidis, P. M. Pardalos

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


To understand basic functional mechanisms that cause epileptic seizures, the paper discusses some key features of theoretical brain functioning models. The hypothesis is put forward that a plausible reason for seizures is pathological feedback in brain circuitry. The analysis of such circuitry has an interesting physical interpretation and may be used to cure epilepsy.

Original languageEnglish (US)
Pages (from-to)483-495
Number of pages13
JournalCybernetics and Systems Analysis
Issue number4
StatePublished - Jul 2006


  • Coupled-oscillator model
  • Epileptic seizure
  • Feedback control system

ASJC Scopus subject areas

  • Computer Science(all)


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