A concise synthesis of substituted 4-alkylaminopyrazolo[3,4-d]pyrimidines

Sidney M. Hecht, Dieter Werner

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


4-Alkylamino-1-methylpyrazolo[3,4-d]pyrimidine-3-carbonitriles have been synthesised in 54-81% yields by condensation of N-substituted amides with 5-amino-1-methylpyrazole-3,4-dicarbonitrile via a Dimroth rearrangement in what is formally an anhydrous medium; the procedure thus permits the synthesis of pyrazolo[3,4-d]-pyrimidines with substituents sensitive to hydration.

Original languageEnglish (US)
Pages (from-to)1903-1906
Number of pages4
JournalJournal of the Chemical Society, Perkin Transactions 1
StatePublished - 1973
Externally publishedYes

ASJC Scopus subject areas

  • General Chemistry


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