5-Propynyluracil·diaminopurine: an efficient base-pair for non-enzymatic transcription of DNA

John C. Chaput, Surajit Sinha, Christopher Switzer

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

The Up·D base-pair (5-propynyl uracil·diaminopurine) is found to be more effective at non-enzymatic transcription than the corresponding natural T·A pair; under non-enzymatic reaction conditions where the natural T·A base-pair fails, a DNA template bearing Up efficiently directs the incorporation of D into a product RNA strand.

Original languageEnglish (US)
Pages (from-to)1568-1569
Number of pages2
JournalChemical Communications
Volume2
Issue number15
DOIs
StatePublished - 2002
Externally publishedYes

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • General Chemistry
  • Catalysis

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