Yuxiang Zhu, Dharneedar Ravichandran, Kenan Song

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Nearly 1 in 4 women undergo surgery for pelvic organ prolapse or urinary incontinence in the US. The weakened pelvic floor, which could be caused by childbirth injury, aging, or obesity, fails to support the pelvic organs, resulting in urinary incontinence, sexual difficulties, and pelvic organ prolapse (POP). Polypropylene (PP) meshes are often used in reconstructive surgeries as a reinforcement to provide long-term, durable support. However, commercial polypropylene meshes have a risk of complications, such as pain, mesh erosion, and infection. The United States Food and Drug Administration (FDA) has consequently re-classified the polypropylene mesh as a high-risk device. Therefore, the need for new meshes to cure POP with a rapid prototyping technique is urgent, especially for personalized medicine. Therefore, we developed a new implantable mesh using biocompatible polymers (e.g., gelatin, polyvinyl alcohol (PVA), chitosan) with controlled bonding strength and tunable lifetime. Our group has leveraged additive manufacturing for porous scaffold structures beneficial for cell attachment and nutrition transmission. Our POP scaffold mesh has demonstrated high biocompatibility and controlled biodegradability. We will also leverage our manufacturing expertise and clinical partnerships to examine cell proliferation and differentiation for tissue regeneration. Our advanced manufacturing method is compatible with other materials and has potential use in layered structures for dental, heart, or bone engineering applications.

Original languageEnglish (US)
Title of host publicationAdditive Manufacturing; Biomanufacturing; Life Cycle Engineering; Manufacturing Equipment and Automation; Nano/Micro/Meso Manufacturing
PublisherAmerican Society of Mechanical Engineers
ISBN (Electronic)9780791885802
StatePublished - 2022
EventASME 2022 17th International Manufacturing Science and Engineering Conference, MSEC 2022 - West Lafayette, United States
Duration: Jun 27 2022Jul 1 2022

Publication series

NameProceedings of ASME 2022 17th International Manufacturing Science and Engineering Conference, MSEC 2022


ConferenceASME 2022 17th International Manufacturing Science and Engineering Conference, MSEC 2022
Country/TerritoryUnited States
CityWest Lafayette


  • Advanced Manufacturing
  • Biocompatible Polymer
  • Biodegradability
  • Pelvic Floor Prolapse
  • Polyvinyl Alcohol
  • Tissue Regeneration

ASJC Scopus subject areas

  • Industrial and Manufacturing Engineering


Dive into the research topics of '3D PRINTED PELVIC ORGAN PROLAPSE (POP) TISSUE SCAFFOLDS'. Together they form a unique fingerprint.

Cite this