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Collaborations and top research areas from the last five years
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Pharmacological tools to modulate ordered membrane domains and order-dependent protein function
Stefanski, K. M., Huang, H., Luu, D. D., Li, G. C., Hutchison, J. M., Saksena, N., Fisch, A. J., Hasaka, T. P., Bauer, J. A., Kenworthy, A. K., Van Horn, W. D. & Sanders, C. R., Dec 2026, In: Communications Chemistry. 9, 1, 72.Research output: Contribution to journal › Article › peer-review
Open Access -
Detection of non-native species formed during fibrillization of the myocilin olfactomedin domain
Scelsi, H. F., Close, E. G. S., Huard, D. J. E., Dunn, E., Bogdanović, N., Mudiyanselage, S. H. W., Grant, A., Stagg, S. M., Schmidt-Krey, I., Van Horn, W. D. & Lieberman, R. L., Apr 2025, In: Protein Science. 34, 4, e70063.Research output: Contribution to journal › Article › peer-review
Open Access -
TRPM8 Protein Dynamics Correlates with Ligand Structure and Cellular Function
Mebrat, M. D., Luu, D. D., Hilton, J. K., Kim, M., Parrott, K., Cherry, B. R., Levitus, M., Journigan, V. B. & Van Horn, W. D., Jun 4 2025, In: Journal of the American Chemical Society. 147, 22, p. 18460-18474 15 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Scopus citations -
Veraguamide E, a Marine Cyanobacterial Depsipeptide Targeting σ2R/TMEM97: Chemical and Neurobiological Characterization
Sotelo-Morales, J. E., Mofidi Tabatabaei, S., Fofie, C. K., Fosu, K. K., Dodd-O, J. B., Simcik, R. D., Tack, S. H., Soto-Reyes, M. J., Yousuf, M. S., Caro-Diaz, E. J. E., Kumar, V. A., Van Horn, W. D., Kolber, B. & Tidgewell, K. J., Nov 28 2025, In: Journal of Natural Products. 88, 11, p. 2736-2749 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Competition between inside-out unfolding and pathogenic aggregation in an amyloid-forming β-propeller
Saccuzzo, E. G., Mebrat, M. D., Scelsi, H. F., Kim, M., Ma, M. T., Su, X., Hill, S. E., Rheaume, E., Li, R., Torres, M. P., Gumbart, J. C., Van Horn, W. D. & Lieberman, R. L., Dec 2024, In: Nature communications. 15, 1, 155.Research output: Contribution to journal › Article › peer-review
Open Access6 Link opens in a new tab Scopus citations
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Understanding human TRPV1 polymodal activation
Van Horn, W. (PI) & Singharoy, A. (CoI)
HHS: National Institutes of Health (NIH)
6/15/22 → 4/30/27
Project: Research project
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Planning Study for the Development of Sigma 2 ligands as Analgesics
Van Horn, W. (PI)
HHS: National Institutes of Health (NIH)
9/11/23 → 8/31/25
Project: Research project
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Comparative study of human and rat TRPV1 transmembrane domain and its role in thermosensing and agonist activation
Van Horn, W. (CoI)
1/1/23 → 12/31/24
Project: Research project
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Molecular Mechanisms and Regulation Networks of TRPM8
Van Horn, W. (PI)
HHS: National Institutes of Health (NIH)
5/1/21 → 2/28/26
Project: Research project
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Characterization of Purified Myocilin: Glaucome as a Protein Misfolding Disease
Van Horn, W. (PI)
HHS: National Institutes of Health (NIH)
3/1/21 → 2/28/25
Project: Research project
Datasets
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Structural Basis for KCNE3 and Estrogen Modulation of the KCNQ1 Channel
Kroncke, B. M. (Contributor), Van Horn, W. D. (Contributor), Smith, J. (Contributor), Kang, C. (Contributor), Welch, R. C. (Contributor), Song, Y. (Contributor), Nannemann, D. P. (Contributor), Taylor, K. C. (Contributor), Sisco, N. J. (Contributor), George, A. L. (Contributor), Meiler, J. (Contributor), Vanoye, C. G. (Contributor) & Sanders, C. R. (Contributor), Protein Data Bank (PDB), Sep 21 2016
DOI: 10.2210/pdb2NDJ/pdb, https://www.wwpdb.org/pdb?id=pdb_00002ndj
Dataset
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2NDJ : Structural Basis for KCNE3 and Estrogen Modulation of the KCNQ1 Channel
Kroncke, B. M. (Contributor), Van Horn, W. D. (Contributor), Smith, J. (Contributor), Kang, C. (Contributor), Welch, R. C. (Contributor), Song, Y. (Contributor), Nannemann, D. P. (Contributor), Sisco, N. J. (Contributor), George, A. L. (Contributor), Meiler, J. (Contributor), Vanoye, C. G. (Contributor) & Sanders, C. R. (Contributor), RCSB-PDB, 2016
DOI: 10.2210/pdb2ndj/pdb, https://www.rcsb.org/structure/2NDJ
Dataset
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Structure of a new variant of GNCA ancestral beta-lactamase
Modi, T. (Contributor), Risso, V. A. (Contributor), Martinez-Rodriguez, S. (Contributor), Gavira, J. A. (Contributor), Mebrat, M. D. (Contributor), Van Horn, W. D. (Contributor), Sanchez-Ruiz, J. M. (Contributor) & Banu, O. S. (Contributor), Protein Data Bank (PDB), Mar 3 2021
DOI: 10.2210/pdb6YRS/pdb, https://www.wwpdb.org/pdb?id=pdb_00006yrs
Dataset
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Structure of F. tularensis Virulence Determinant
Zook, J. (Contributor), Mo, G. (Contributor), Sisco, N. J. (Contributor), Craciunescu, F. M. (Contributor), Hansen, D. T. (Contributor), Baravati, B. (Contributor), Cherry, B. R. (Contributor), Sykes, K. (Contributor), Wachter, R. (Contributor), Van Horn, W. D. (Contributor) & Fromme, P. (Contributor), Protein Data Bank (PDB), Jun 10 2015
DOI: 10.2210/pdb2MU4/pdb, https://www.wwpdb.org/pdb?id=pdb_00002mu4
Dataset
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2MU4 : Structure of F. tularensis Virulence Determinant
Zook, J. (Contributor), Mo, G. (Contributor), Sisco, N. J. (Contributor), Craciunescu, F. M. (Contributor), Hansen, D. T. (Contributor), Baravati, B. (Contributor), Cherry, B. R. (Contributor), Van Horn, W. D. (Contributor) & Fromme, P. (Contributor), RCSB-PDB, 2015
DOI: 10.2210/pdb2mu4/pdb, https://www.rcsb.org/structure/2MU4
Dataset