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- 1 Similar Profiles
Collaborations and top research areas from the last five years
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Discovery and Functional Characterization of a Potent, Selective, and Metabolically Stable PROTAC of the Protein Kinases DYRK1A and DYRK1B
Wilms, G., Schofield, K., Maddern, S., Foley, C., Shaw, Y., Smith, B., Basantes, L. E., Schwandt, K., Babendreyer, A., Chavez, T., McKee, N., Gokhale, V., Kallabis, S., Meissner, F., Rokey, S. N., Dunckley, T., Montfort, W. R., Becker, W. & Hulme, C., Oct 10 2024, In: Journal of Medicinal Chemistry. 67, 19, p. 17259-17289 31 p.Research output: Contribution to journal › Article › peer-review
10 Link opens in a new tab Scopus citations -
Mechanism-free repurposing of drugs for C9orf72-related ALS/FTD using large-scale genomic data
The International ALS Genomics Consortium, ITALSGEN Consortium, SLAGEN Consortium, Project MinE ALS Sequencing Consortium & The American Genome Center, Nov 13 2024, In: Cell Genomics. 4, 11, 100679.Research output: Contribution to journal › Article › peer-review
Open Access7 Link opens in a new tab Scopus citations -
Genome-wide structural variant analysis identifies risk loci for non-Alzheimer's dementias
PROSPECT Consortium, The American Genome Center, International LBD Genomics Consortium & International ALS/FTD Consortium, Jun 14 2023, In: Cell Genomics. 3, 6, 100316.Research output: Contribution to journal › Article › peer-review
Open Access19 Link opens in a new tab Scopus citations -
DYRK1A antagonists rescue degeneration and behavioural deficits of in vivo models based on amyloid-β, Tau and DYRK1A neurotoxicity
Zhu, B., Parsons, T., Foley, C., Shaw, Y., Dunckley, T., Hulme, C. & Hodge, J. J. L., Dec 2022, In: Scientific reports. 12, 1, 15847.Research output: Contribution to journal › Article › peer-review
Open Access14 Link opens in a new tab Scopus citations -
The Omnipresence of DYRK1A in Human Diseases
Deboever, E., Fistrovich, A., Hulme, C. & Dunckley, T., Aug 2022, In: International journal of molecular sciences. 23, 16, 9355.Research output: Contribution to journal › Review article › peer-review
Open Access54 Link opens in a new tab Scopus citations
Projects
- 6 Finished
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DYRK1A inhibition as a novel treatment approach for Alzheimer's disease - Resubmission
Dunckley, T. (PI)
HHS: National Institutes of Health (NIH)
4/1/20 → 2/29/24
Project: Research project
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Comprehensive Methylation Profiling of the PPMI Cohort
Dunckley, T. (PI)
10/1/18 → 4/14/23
Project: Research project
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Optimization of Selective DYRK1A Inhibitors as a Treatment for AD
Dunckley, T. (PI)
Alzheimer's Drug Discovery Foundation
6/1/18 → 5/31/19
Project: Research project
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Development of selective DYRK1A inhibitors as a treatment for Alzheimers disease
Dunckley, T. (PI)
Harrington Discovery Institute
1/4/17 → 12/31/19
Project: Research project
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Testing of selective DYRK1A inhibitors as a novel treatment of AD
Dunckley, T. (PI)
Alzheimer's Drug Discovery Foundation
4/1/16 → 2/28/18
Project: Research project
Datasets
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DNA methylation changes associated with Parkinson’s disease progression: outcomes from the first longitudinal genome-wide methylation analysis in blood
Henderson-Smith, A. (Creator), Fisch, K. M. (Creator), Hua, J. (Creator), Liu, G. (Creator), Ricciardelli, E. (Creator), Jepsen, K. (Creator), Huentelman, M. (Creator), Stalberg, G. (Creator), Edland, S. D. (Creator), Scherzer, C. R. (Creator), Dunckley, T. (Creator) & Desplats, P. (Creator), Taylor & Francis, 2023
DOI: 10.6084/m9.figshare.7850735, https://tandf.figshare.com/articles/dataset/DNA_methylation_changes_associated_with_Parkinson_s_disease_progression_outcomes_from_the_first_longitudinal_genome-wide_methylation_analysis_in_blood/7850735
Dataset
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DNA methylation changes associated with Parkinson’s disease progression: outcomes from the first longitudinal genome-wide methylation analysis in blood
Henderson-Smith, A. (Creator), Fisch, K. M. (Creator), Hua, J. (Creator), Liu, G. (Creator), Ricciardelli, E. (Creator), Jepsen, K. (Creator), Huentelman, M. (Creator), Stalberg, G. (Creator), Edland, S. D. (Creator), Scherzer, C. R. (Creator), Dunckley, T. (Creator) & Desplats, P. (Creator), Taylor & Francis, 2023
DOI: 10.6084/m9.figshare.7850735.v2, https://tandf.figshare.com/articles/dataset/DNA_methylation_changes_associated_with_Parkinson_s_disease_progression_outcomes_from_the_first_longitudinal_genome-wide_methylation_analysis_in_blood/7850735/2
Dataset
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DNA methylation changes associated with Parkinson’s disease progression: outcomes from the first longitudinal genome-wide methylation analysis in blood
Henderson-Smith, A. (Creator), Fisch, K. M. (Creator), Hua, J. (Creator), Liu, G. (Creator), Ricciardelli, E. (Creator), Jepsen, K. (Creator), Huentelman, M. (Creator), Stalberg, G. (Creator), Edland, S. D. (Creator), Scherzer, C. R. (Contributor), Dunckley, T. (Creator) & Desplats, P. (Creator), figshare Academic Research System, 2019
DOI: 10.6084/m9.figshare.7850735.v1, https://tandf.figshare.com/articles/dataset/DNA_methylation_changes_associated_with_Parkinson_s_disease_progression_outcomes_from_the_first_longitudinal_genome-wide_methylation_analysis_in_blood/7850735/1
Dataset