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Collaborations and top research areas from the last five years
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A protein dynamics–based deep learning model enhances predictions of fitness and epistasis
Huynh, N., Kazan, I. C., Lu, J., Kolbaba-Kartchner, B., Mills, J. H. & Ozkan, S. B., Oct 21 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 42, e2502444122.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations -
Fluorescent Protein Chromophore-Based Luciferins for Bioluminescence Imaging
Mangubat-Medina, A. E., Torrey, Z. R., Townsend, K. M., Kolbaba-Kartchner, B., Mills, J. H. & Prescher, J. A., Dec 22 2025, In: Chemical and Biomedical Imaging. 3, 12, p. 857-864 8 p.Research output: Contribution to journal › Article › peer-review
Open Access -
A Massively Parallel In Vivo Assay of TdT Mutants Yields Variants with Altered Nucleotide Insertion Biases
Carlson, C. K., Loveless, T. B., Milisavljevic, M., Kelly, P. I., Mills, J. H., Tyo, K. E. J. & Liu, C. C., Oct 18 2024, In: ACS Synthetic Biology. 13, 10, p. 3326-3343 18 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Link opens in a new tab Scopus citations -
Expedient Synthesis and Characterization of π-Extended Luciferins
Caldwell, D. R., Townsend, K. M., Kolbaba-Kartchner, B., Hadjian, T., Ivanic, J., Love, A. C., Malvar, B., Mills, J., Prescher, J. A. & Schnermann, M. J., Oct 18 2024, In: Journal of Organic Chemistry. 89, 20, p. 14625-14633 9 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Scopus citations -
Greasy proteins made easy
Mills, J. H., Jan 2024, In: Nature Chemical Biology. 20, 1, p. 4-5 2 p.Research output: Contribution to journal › Article › peer-review
Projects
- 9 Finished
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High-end MALDI Time of Flight Mass Spectrometer for Bioanalysis
Velazquez, R. (CoI), Fromme, P. (CoI), Moore, G. (CoI), Mills, J. (CoI), Moore, A. (CoI), Borges, C. (CoI), Stephanopoulos, N. (CoI), Vaiana, S. (CoI), Sandrin, T. (CoI), Ros, A. (PI), Mastroeni, D. (CoI), Hecht, S. (CoI) & Long, T. (CoI)
HHS: National Institutes of Health (NIH)
8/15/22 → 8/14/23
Project: Research project
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Purification and Characterization of a toxic AD associated intracellularly generated amyloid beta fragment
Nannenga, B. (CoI), Sierks, M. (PI) & Mills, J. (CoI)
HHS: National Institutes of Health (NIH)
8/1/22 → 7/31/25
Project: Research project
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Expanding the fluorescent toolkit with non-canonical amino acids
Mills, J. (PI)
HHS: National Institutes of Health (NIH)
4/1/20 → 3/31/25
Project: Research project
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Genetically encodable epitopes to overcome size and resolution limits in cryo-EM - Resubmission - 1
Mills, J. (PI) & Nannenga, B. (CoI)
HHS: National Institutes of Health (NIH)
9/15/19 → 6/30/22
Project: Research project
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IIBR RoL: Development of enhanced computational protein design methods using a metaanalysis of enzyme dynamics
Mills, J. (PI) & Ozkan, B. (CoI)
National Science Foundation (NSF)
9/1/19 → 8/31/23
Project: Research project
Datasets
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Spectroscopic and structural characterization of a genetically encoded direct sensor for protein-ligand interactions
Gleason, P. R. (Contributor), Kolbaba-Kartchner, B. (Contributor), Henderson, J. N. (Contributor), Stahl, E. P. (Contributor), Simmons, C. R. (Contributor) & Mills, J. H. (Contributor), Protein Data Bank (PDB), Sep 23 2020
DOI: 10.2210/pdb6UDB/pdb, https://www.wwpdb.org/pdb?id=pdb_00006udb
Dataset
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4IWW : Computational Design of an Unnatural Amino Acid Metalloprotein with Atomic Level Accuracy
Mills, J. H. (Contributor), Baker, D. (Contributor), Khare, S. D. (Contributor), Bolduc, J. M. (Contributor) & Stoddard, B. L. (Contributor), RCSB-PDB, 2013
DOI: 10.2210/pdb4iww/pdb, https://www.rcsb.org/structure/4IWW
Dataset
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Spectroscopic and structural characterization of a genetically encoded direct sensor for protein-ligand interactions
Gleason, P. R. (Contributor), Kolbaba-Kartchner, B. (Contributor), Henderson, J. N. (Contributor), Stahl, E. P. (Contributor), Simmons, C. R. (Contributor) & Mills, J. H. (Contributor), Protein Data Bank (PDB), Sep 23 2020
DOI: 10.2210/pdb6UDC/pdb, https://www.wwpdb.org/pdb?id=pdb_00006udc
Dataset
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Crystal Structure of the Fab fragment of humanized 5c8 antibody containing the fluorescent non-canonical amino acid L-(7-hydroxycoumarin-4-yl)ethylglycine at pH 9.7
Henderson, J. N. (Contributor), Simmons, C. R. (Contributor), Fahmi, N. E. (Contributor), Jeffs, J. W. (Contributor), Borges, C. R. (Contributor) & Mills, J. H. (Contributor), Protein Data Bank (PDB), Dec 23 2020
DOI: 10.2210/pdb6W5A/pdb, https://www.wwpdb.org/pdb?id=pdb_00006w5a
Dataset
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Crystal Structure of the Fab fragment of humanized 5c8 antibody containing the fluorescent non-canonical amino acid L-(7-hydroxycoumarin-4-yl)ethylglycine at pH 5.5
Henderson, J. N. (Contributor), Simmons, C. R. (Contributor), Fahmi, N. E. (Contributor), Jeffs, J. W. (Contributor), Borges, C. R. (Contributor) & Mills, J. H. (Contributor), Protein Data Bank (PDB), Nov 14 2018
DOI: 10.2210/pdb6BJZ/pdb, https://www.wwpdb.org/pdb?id=pdb_00006bjz
Dataset