Additional file 6 of A Cas9-mediated adenosine transient reporter enables enrichment of ABE-targeted cells

Additional file 6: Fig. S6. Comparison of bystander editing in mCherry/GFP double positive and unsorted HEK293 cell populations using XMAS-TREE. Distribution of bystander edits at target loci in mCherry/GFP double positive and unsorted cell populations using XMAS-TREE based strategies in the context of (a) singleplex and (b) multiplex editing. Orange indicates target A within the editing window. Light grey indicates bystander A within the editing window. Bystander ratio was computed as the frequency of editing the bystander A divided by the percentage of editing at the target A. P-value given for Student’s t-test comparing bystander ratio in mCherry/GFP double positive versus unsorted cells at an indicated bystander A. n = 3